tag:blogger.com,1999:blog-1812431336777691886.post5468639187663573737..comments2024-02-29T03:57:00.088-05:00Comments on The Mermaid's Tale: Some genetic non-sense about nonsense genesAnne Buchananhttp://www.blogger.com/profile/09212151396672651221noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-1812431336777691886.post-61539336299838378362017-04-21T14:40:59.989-04:002017-04-21T14:40:59.989-04:00In the post, I mentioned the background inbreeding...In the post, I mentioned the background inbreeding that must be in the same data (but not leading to detectable double KOs), and of course each person's inbreeding homozygosity will affect different genome regions. Thinking rather cursorily, this likely will have no systematic effect, but on average will reduce the level of heterozygosity and hence of potential functional redundancy, in the population. This, if correct, would mean that the level of redundancy that effectively protects against gene loss, is enough to be robust to loss of variation due to this genomewide inbreeding effect.Ken Weisshttps://www.blogger.com/profile/02049713123559138421noreply@blogger.com