tag:blogger.com,1999:blog-1812431336777691886.post4628485379194868385..comments2024-02-29T03:57:00.088-05:00Comments on The Mermaid's Tale: Somatic mutation and neurological traits. Part II. Relevant Somatic Mutation discovered?Anne Buchananhttp://www.blogger.com/profile/09212151396672651221noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-1812431336777691886.post-28703618218408183632016-02-17T14:33:50.030-05:002016-02-17T14:33:50.030-05:00This is a bit beyond what I ca comment knowledgeab...This is a bit beyond what I ca comment knowledgeably on, but reading the paper might clarify for you. However, as I understand it the author used some recombination-repair-deficient mouse cells, to see the rearrangements that occurred, but did not interpret the results to mean that in 'normal' cells all the double-strand breaks were repaired. You should check the paper or the commentary. If you can't get access I can email pdf's to you.Ken Weisshttps://www.blogger.com/profile/02049713123559138421noreply@blogger.comtag:blogger.com,1999:blog-1812431336777691886.post-3242947410493474302016-02-17T14:15:03.944-05:002016-02-17T14:15:03.944-05:00Is this mutation, or is it programmed in an analog...Is this mutation, or is it programmed in an analogous way to antibody VDJ recombination? If there were VDJ-like "shuffling" of modular genes in particular cell lineages, how would we know?Peterhttps://www.blogger.com/profile/12559721137290332762noreply@blogger.comtag:blogger.com,1999:blog-1812431336777691886.post-64986650689919451652016-02-17T08:22:21.686-05:002016-02-17T08:22:21.686-05:00I hadn't thought of that possibility, since I&...I hadn't thought of that possibility, since I'm not a clinician of any sort. But testing the idea could have even broader implications--even if it showed that the idea was just baloney.Ken Weisshttps://www.blogger.com/profile/02049713123559138421noreply@blogger.comtag:blogger.com,1999:blog-1812431336777691886.post-81147920338859410492016-02-17T08:10:44.848-05:002016-02-17T08:10:44.848-05:00I am surprised that this study has not been done. ...I am surprised that this study has not been done. Some patients with a single epileptic focus in a non-critical area will have the focus resected. Someone needs to collect some of those cases, pull the paraffin blocks, and sequence the genomes of the neurons in the epileptic foci. I am sure that the results would be fascinating one way or the other,Michael Finfer, MDnoreply@blogger.com