tag:blogger.com,1999:blog-1812431336777691886.post3869355943827464802..comments2024-02-29T03:57:00.088-05:00Comments on The Mermaid's Tale: Science, causality and beliefAnne Buchananhttp://www.blogger.com/profile/09212151396672651221noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-1812431336777691886.post-73405936719316204562015-03-23T19:35:57.309-04:002015-03-23T19:35:57.309-04:00Polygenic traits are almost always modeled as if t...Polygenic traits are almost always modeled as if they are additive. But we know that is generally not true, in that interactions are the basis of all the effects. But it is essentially intractable to deal with more than one or a very few, basically strong and consistent interactions. And interactions with the environment clearly happen and probably between a given dose of environmental effect and a genetic variant (here, one needs to be clear what 'environment' means, since one gene's environment includes the rest of the genome, the cell, the organ, the individual and the external environment.Ken Weisshttps://www.blogger.com/profile/02049713123559138421noreply@blogger.comtag:blogger.com,1999:blog-1812431336777691886.post-72015587410060451792015-03-23T18:28:09.205-04:002015-03-23T18:28:09.205-04:00thanks for reply, what aboutt the genes for the po...thanks for reply, what aboutt the genes for the polygenic traits, like height? do the genes have a additive effect? or is it also dependent on environment if gene will express?giorgionoreply@blogger.comtag:blogger.com,1999:blog-1812431336777691886.post-77493757662938385752015-03-23T09:01:01.729-04:002015-03-23T09:01:01.729-04:00The 'environment' of every point along the...The 'environment' of every point along the genome includes the rest of the genome, the cell, the organ, the body, and the outside. So in that sense, no, every site depends on the environment for what it does.<br /><br />But if you really mean just the external environment then, yes, most of the genome's functions have to do with things inside the cell or among cells, that are not directly related to the external environment, except in the very generic sense that there must be oxygen, water, food, and so on.Ken Weisshttps://www.blogger.com/profile/02049713123559138421noreply@blogger.comtag:blogger.com,1999:blog-1812431336777691886.post-4472575286381040262015-03-22T23:34:07.481-04:002015-03-22T23:34:07.481-04:00are there any genes of the siginificant human trai...are there any genes of the siginificant human traits that have any effect independent of environment?giorgionoreply@blogger.com